The Aucoin Research Group is focused on complex biologics. Biologics are biological products i.e. products that are derived from living organisms or are the organisms themselves. More specifically, our group focusses on cell culture, growing populations of individual cells that are either themselves the products or that make a specific type of protein, nucleic acid, lipid or combination thereof.

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Since the onset of the 2020 COVID19 pandemic, our lab has directed all of our efforts towards research that could help in these trying times.

To do this,

  1. we have increased our efforts to make a suspension Vero cell line;

  2. we are building a phage-based dual modality vaccine candidate against SARS-CoV-2;

  3. we are investigating the susceptibility of coronaviruses to UV;

  4. we are enabling ELISA based technologies towards an immunity passport;

  5. we are supporting local and regional companies test their technologies with coronaviruses.

These are some of the research projects that have been on-going in the Aucoin Group prepandemic:

  1. Development of a cellular model that can be used to improve process conditions for the production of complex biologics with a focus on influenza virus-like particles and adeno-associated virus vectors

  2. Development of metabolomic tools for improving yield and critical quality attributes of antibodies

  3. Development of a suspension culture Vero cell line to investigate the infection and recovery of Herpes simplex virus type 2 in high cell density cultures

  4. Development of a microfluidic based infectious virus detection and quantification device

  5. Development of NMR-based metabolomics for assessing the human microbiota and the links to neonatal necrotizing enterocolitis

  6. Assessment of UV damage of cell culture process fluids for use as a barrier against adventitious agents or terminal sterilization techniques

  7. Development of NMR-based targeted profiling of hydrolysates for use in quality assurance and in the creation of a chemically defined medium

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