InTheDark

Publications

2021

    Works by Walji and Yen currently under review with hopes of being published soon!

2020

  • Wulff D, Chan A, Liu Q, Gu F X, Aucoin MG, Characterizing internal cavity modulation of corn starch microcapsules. Accepted Heliyon.
  • Quattrociocchi M, Boegel SJ, Aucoin MG. Enhanced characterization of yeast hydrolysate combining acid digestion and 1D-1H NMR targeted profiling. Accepted Canadian Journal of Chemical Engineering.
  • Ganobis CM, Al-Abdul-Wahid MS, Renwick S, Yen S, Carriero C, Aucoin MG, Allen-Vercoe E. 1D 1H NMR as a tool for fecal metabolomics. (2020) Current Protocols in Chemical Biology, 12, e83. doi: 10.1002/cpch.83
  • Moussa HI, Chan WY, Logan M, Aucoin MG, Tsui TY. Limitation in controlling the morphology of mammalian Vero cells induced by cell division on asymmetric tungsten-silicon oxide nanocomposite. Materials (MDPI) 2020, 13(2), 335
  • Walji SD, Tanvir S, Aucoin MG, Anderson WA. Testing the effect of faucet flowrate on handwashing efficacy. CSA GROUP. 2020
  • Walji SD, Aucoin MG. A Critical Evaluation of Current Protocols for Self-Sterilizing Surfaces Designed to Reduce Viral Nosocomial Infections. In press. American Journal of Infection Control (Elsevier)
  • Wulff D, Aucoin MG, Gu F. Helium ion microscopy of corn starch. Starch (Wiley) In press.

2019

2018

  • Moussa HI, Logan M, Wong K, Rao Z, Aucoin MG, Tsui TY. Nano-scale-Textured Surfaces for Mammalian Cell Alignment (2018) Micromachines, 9 (98), art. no. 464.
  • Blondeel, EJM, Aucoin MG. Supplementing glycosylation: A review of applying nucleotide-sugar precursors to growth medium to affect therapeutic recombinant protein glycoform distributions (2018) Biotechnology Advances, 36 (5), pp. 1505-1523.
  • Moussa HI, Logan M, Chan WY, Wong K, Rao Z, Aucoin MG, Tsui TY. Pattern-dependent mammalian cell (Vero) morphology on tantalum/silicon oxide 3D nanocomposites (2018) Materials, 11 (8), art. no. 1306.
  • Yen S, Bolte E, Aucoin M, Allen-Vercoe E. Metabonomic evaluation of fecal water preparation methods: the effect of ultracentrifugation (2018) Current Metabolomics, 6, pp. 57-63.

2017

  • Moussa HI, Logan M, Siow GC, Phann DL, Rao Z, Aucoin MG, Tsui TY. (2017) Manipulating mammalian cell morphologies using chemical-mechanical polished integrated circuit chips. Science and Technology of Advanced Materials. 18(1): 839-856
  • Dare EV, Gabriel M, Begum A, Sasges M, Aucoin MG. (2017) The effect of hydrogen peroxide produced during ultraviolet disinfection of CHO cell culture media. Process Biochemistry. (in press) http://dx.doi.org/10.1016/j.procbio.2017.06.025
  • Meunier SM, Sasges M, Aucoin MG. (2017) Evaluating Ultraviolet Sensitivity of Adventitious Agents in Biopharmaceutical Manufacturing. Journal of Industrial Microbiology & Biotechnology. 44:893–909
  • Srirangan K, Stacey LE, Newton C, Akawi LK, Chou CP, Aucoin MG. (2017) Use of a case on metabolically engineered Escherichia coli to develop a framework for the design and analysis of bioprocesses. International Journal of Engineering Education. 33(2(A)): 751–760

2016

  • Blondeel, E.J.M., Ho, R., Schulze, S., Sokolenko, S., Guillemette, S.R., Slivac, I., Durocher, Y., Guillemette, J.G., McConkey, B.J., Chang, D., Aucoin, M.G. An omics approach to rational feed: Enhancing growth in CHO cultures with NMR metabolomics and 2D-DIGE proteomics (2016) Journal of Biotechnology, 234, pp. 127-138.
  • Sokolenko, S., Quattrociocchi, M., Aucoin, M.G. Identifying model error in metabolic flux analysis - a generalized least squares approach (2016) BMC Systems Biology, 10 (1), art. no. 91
  • Meunier, S.M., Todorovic, B., Dare, E.V., Begum, A., Guillemette, S., Wenger, A., Saxena, P., Campbell, J.L., Sasges, M., Aucoin, M.G. Impact of dissolved oxygen during UV-irradiation on the chemical composition and function of CHO cell culture media (2016) PLoS ONE, 11 (3), art. no. e0150957
  • Thompson, C.M., Montes, J., Aucoin, M.G., Kamen, A.A. Recombinant protein production in large-scale agitated bioreactors using the baculovirus expression vector system (2016) Methods in Molecular Biology, 1350, pp. 241-261.
  • Thompson, C.M., Aucoin, M.G., Kamen, A.A. Production of virus-like particles for vaccination (2016) Methods in Molecular Biology, 1350, pp. 299-315.
  • Pyne, M.E., Sokolenko, S., Liu, X., Srirangan, K., Bruder, M.R., Aucoin, M.G., Moo-Young, M., Chung, D.A., Chou, C.P.Disruption of the reductive 1,3-propanediol pathway triggers production of 1,2-propanediol for sustained glycerol fermentation by Clostridium pasteurianum (2016) Applied and Environmental Microbiology, 82 (17), pp. 5375-5388.

2015

  • Bradley RM, Marvyn PM, Henao JJA, Mardian EB, George S, Aucoin MG, Stark KD, Duncan RE. Acylglycerophosphate acyltransferase 4(AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids 1851(12), 2015, 1566-1576 DOI:10.1016/j.bbalip.2015.09.005
  • Blondeel EJM, Braasch K, McGill T, Chang D, Engel C, Spearman M, Butler M, Aucoin MG. Tuning a MAb glycan profile in cell culture: Supplementing N-acetylglucosamine to favour G0 glycans without compromising productivity and cell growth. Journal of Biotechnology 214, 2015, 105-112 DOI:10.1016/j.jbiotec.2015.09.014
  • Sokolenko S, Aucoin MG. A correction method for systematic error in 1 H-NMR time-course data validated through stochastic cell culture simulation. BMC Systems Biology 9(1), 2015, 51
  • Thompson CM, Petiot E, Mullick A, Aucoin MG, Henry O, Kamen AA. Critical assessment of influenza VLP production in Sf9 and HEK293 expression systems. BMC Biotechnology 15(1), 2015, 31
  • George S, Jauhar AM, Mackenzie J, Kieβlich S, Aucoin MG. Temporal characterization of protein production levels from baculovirus vectors coding for GFP and RFP genes under non-conventional promoter control. Biotechnology and Bioengineering 112(9), 2015, 1822-1831 DOI: 10.1002/bit.25600
  • Yen S, McDonald JAK, Schroeter K, Oliphant K, Sokolenko S, Blondeel EJM, Allen-Vercoe E, Aucoin MG. Metabolomic analysis of human fecal microbiota: a comparison of feces-derived communities and defined mixed communities. Journal of Proteome Research 14(3), 2015, 1472-1482

2014

  • Yen S, Sokolenko S, Manocha B, Blondeel EJM, Aucoin MG, Patras A, Daynouri-Pancino F, Sasges M. Treating cell culture media iwth UV irradiation against adventitious agents: minimal impact on CHO performace. Biotechnology Progress 30(5), 2014, 1190-1195
  • Sokolenko S, Blondeel EJM, Azlah N, George B, Schulze S, Chang D, Aucoin MG. Profiling convoluted single-dimension proton NMR spectra: a Plackett-Burman approach for assessing quantification error of metabolites in complex mixtures with application to cell culture. Analytical Chemistry 86(7), 2014, 3330-3337
  • Suh YH, Kim BJ, Tam KC, Aucoin MG. Dectection and characterization of hemoglobin dissociation and aggregation using microcalorimetry. Journal of Thermal Analysis and Calorimetry 115(3), 2014, 2159-2169

2013

  • Thompson CM, Petiot E, Aucoin MG, Henry O, Kamen AA, Developing a production process for influenza VLPs: a comparison between HEK 293SF and Sf9 prouction platforms. BMC Proceedings 7 (Suppl 6), 2013, P22
  • Srirangan K, Akawi L, Lie X, Westbrook A, Blondeel EJM, Aucoin MG, Moo-Young M, Chou PC, Manipulating the sleeping beauty mutase operon for the production of 1-propanol in engineering Escherichia coli. Biotechnology for Biofuels 6, 2013, 139
  • Nicastro J, Sheldon K, El-Zarkout FA, Sokolenko S, Aucoin MG, Slavcev R, Construction and analysis of a genetically tuneable lytic phage display system. Applied Microbiology and Biotechnology 97(17) 7791-7804 DOI:10.1007/s00253-013-4898-6
  • Sokolenko S, McKay R, Blondeel EJM, Lewis MJ, CHang D, George B, Aucoin MG, Understanding the variability of compound quantification from targeted profiling metaolomics of 1D-1H-NMR spectra in synthetic mixtures and urine with additional insights on choice of pulse sequences and robotic sampling. Metabolomics 9(4), 2013, 887-903 DOI:10.​1007/​s11306-013-0503-3
  • Lai YP, Sun KEK, Moresoli C, Aucoin MG. Designing and undergraduate food processing laboratory for the University of Waterloo. Proceedings of the Canadian Engineering Education Association

2012

  • Sokolenko S, Nicastro J, Slavcev R, Aucoin MG. Graphical analysis of flow cytometer data for characterizing controlled fluorescent protein display on λ phage. Cytometry Part A DOI: 10.1002/cyto.a.22211
  • George S, Sokolenko S, Aucoin MG. Rapid and Cost-Effective Baculovirus Sample Preparation Method as a Viable Alternative to Conventional Preparation for Real Time PCR. Journal of Virological Methods, 182(1–2), 2012, 27–36
  • Sokolenko S, George S, Wagner A, Tuladhar A, Andrich JMS, and Aucoin MG. Co-expression vs co-infection using baculovirus expression vectors in insect cell culture: benefits and drawbacks. Biotechnology Advances, 30(3), 2012, 766–781

2011

  • Kamen AA, Aucoin MG, Merten OW, Alves P, Hashimoto Y, Airenne K, Hu YC, Mezzina M, van Oers MM. An initiative to manufacture and characterize baculovirus reference material. Journal of invertebrate pathology, 107, 2011, S113-7, 2011
  • Transfiguracion J, Mena, Aucoin MG, Kamen AA. Quantification and Validation of Baculovirus Particles using HPLC. Journal of Chromatography B, 879(1), 2011, 61-68

2000-2010

  • Sokolenko S, Cheng Y-L, Aucoin MG. Getting more from cell size distributions: establishing more accurate biovolumes by estimating viable cell populations. Biotechnology Progress, 26(6), 2010, 1787-1795.
  • Aucoin MG, Mena Y, Kamen AA. Bioprocessing of baculovirus vectors: A review. Current Gene Therapy, 10(3), 2010, 174-186
  • Mena JA, Aucoin MG, Montes J, Chahal PS, Kamen AA. Improving Adeno-Associated Vector Yield In High Density Insect Cell Cultures. Journal of Gene Medicine, 12(2), 2010, 157-167
  • Aucoin MG, Jolicoeur M. Is there room in the graduate curriculum to learn how to be a graduate student? An approach using a graduate-level biochemical engineering course. Chemical Engineering Education, 43(4), 2009, 306-312
  • Aucoin MG, Perrier M, Kamen AA. Critical assessment of current adeno-associated viral vector production and quantification methods. Biotechnology Advances, 26(1), 2008, 73-88
  • Aucoin MG, Perrier M, Kamen AA. Improving AAV vector yield in insect cells by modulating the temperature after infection., Biotechnology and Bioengineering, 97(6), 2007, 1501-1509
  • Chahal PS, Aucoin MG, Kamen AA. Primary recovery and chromatographic purification of adeno-associated virus type 2 produced by baculovirus/insect cell system. Journal of Virological Methods, 139(1), 2007, 61-70
  • Aucoin MG, McMurray-Beaulieu V, Poulin F, Boivin EB, Chen JK, Ardelean FM, Cloutier M, Choi YJ, Miguez CB, Jolicoeur M. Identifying conditions for inducible protein production in E. coli: combining a fed-batch and multiple induction approach. Microbial Cell Factories, 5(27), 2006
  • Aucoin MG, Perrier M, Kamen AA. Production of adeno-associated viral vectors in insect cells using triple infection: Optimization of baculovirus concentration ratios. Biotechnology and Bioengineering, 95(6), 2006, 1081 - 1092
  • Meghrous J, Aucoin MG, Jacob D, Chahal PS, Arcand N, Kamen AA. Production of recombinant adeno-associated viral vectors using a baculovirus/insect cell suspension culture system: From shake flasks to a 20-L bioreactor. Biotechnology Progress, 21(1), 2005, 154-160
  • Aucoin MG, Erhardt FA, Legge RL. Hyperactivation of Rhizomucor miehei lipase by hydrophobic xerogels. Biotechnology and Bioengineering, 85(6), 2004, 647-655
  • Aucoin MG, Legge RL. Effects of supercritical CO2 exposure and depressurization on immobilized lipase activity. Biotechnology Letters, 23(22), 2001, 1863-1870